Flash Card 2 Osteolysis

Phagocytes (Macrophage ) engulf debris .

Release of TNF-alpha , TGF-beta ,PDGF

Activate RANK or Osteoblast

Hypothetical model of BDNF-and PTX3-induced osteolysis in bone ...
https://www.researchgate.net/figure/Hypothetical-model-of-BDNF-and-PTX3-induced-osteolysis-in-bone-metastatic-gastric-cancer_fig5_305689959

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